Another mediation analysis was performed only for male patients, testing TT, fT, SHBG, DHEAS, and IGF‐1 as potential mediators of the relationship between L‐TOT and sleep quality, mood (anxiety and depression) role physical, role emotional, fatigue, emotional well‐being, social functioning, and pain (Table 6). The gene discussed is SHBG; the disease is depressive symptom measurement.