In a subsequent meta-analysis of prospective studies involving 25 000 adults with genome-wide association study (GWAS) data and Lp(a) levels, Burgess et al19 identified 43 independent variants associated with Lp(a) that explained ≈63% of variance in Lp(a), and higher genetically predicted Lp(a) levels were log-linearly and positively associated with higher risks of CHD. This evidence concerns the gene LPA and coronary artery disorder.