IFNA1 and systemic lupus erythematosus: In addition, different B cell subsets in SLE patients have different response characteristics to type I and type III IFNs, and patients with high levels of IFI27 have significantly higher levels of IFN-α in peripheral blood mononuclear cells (PBMCs) than patients with low levels of IFI27 or healthy donors (Song et al., 2023).