GSDMD and systemic lupus erythematosus: Neutrophils in SLE release nuclear and mitochondrial DNA (mtDNA), linked to Gasdermin D (GSDMD)-mediated pyroptosis; oxidized mtDNA (Ox-mtDNA) further enhances GSDMD-N oligomerization, amplifying pyroptotic cell death (Miao et al., 2023; Xin et al., 2024).