NUCLEOLIN and neoplasm: Macrophage-derived EVs (Mφ-EVs) are modified using VEGF-siRNA and let-7 miRNA, which target the nucleolin protein (Boimel et al., 2012), nucleolin that plays various roles in the cell, including in the regulation of gene expression, cell proliferation, and tumor development (Burbano De Lara et al., 2021).