The significantly activated signaling pathways included: the interferon (Z-score=2.0), role of pattern recognition receptors in recognition of bacteria and viruses (Z-score=2.0), corticotropin-releasing hormone g (Z-score=2.0), protein kinase A (Z-score=2.111), cardiac hypertrophy (Z-score=2.111), GPCR-mediated nutrient sensing in enteroendocrine cells (Z-score=2.236), P2Y purinergic receptor (Z-score=2.236), AMPK pathway (Z-score=2.236), dopamine-DARPP32 feedback in cAMP (Z-score=2.236), GNRH s (Z-score=2.236), and cardiac hypertrophy signaling pathways (Z-score=2.449). This evidence concerns the gene PPP1R1B and cardiac hypertrophy.