The mechanism responsible for the efficacy of OK-432 therapy involves the intense production of cytokines, including interleukin 6 (IL-6), interleukin 8 (IL-8), interferon-gamma (IFN-γ), interferon-alpha (IFN-α), vascular endothelial growth factor (VEGF), and periostin, through the activation of monocytes and neutrophils.29This mechanism leads to a reduction in cyst volume and the generation of fibrotic adhesion within the cystic cavity. The gene discussed is POSTN; the disease is cyst.