ISG15 and migraine disorder: Analysis of the group of migraine patients and controls highlighted 4 upregulated (‘Metabolism’, ‘Phase II- conjugation of compounds’, ‘Biological oxidations’, ‘Glucuronidation’) and 7 downregulated pathways (‘Interferon gamma signaling’, ‘ISG15 antiviral mechanism’, ‘Immune system’, ‘Cytokine signaling in immune system’, ‘antiviral mechanism by IFN-stimulated genes’, ‘Interferon signaling’, ‘Interferon alpha/beta signaling’) with FDR < 0.5 (Fig. 5).