Since prior studies with purified HTRA1 protein demonstrated similar effects with other aggregation-prone proteins such as FUS, TDP-4319 and fibrillar tau26,27, it would be of interest to examine whether NALL treatment exhibited protective effects in models of amyotrophic lateral sclerosis, frontotemporal dementia, and Alzheimer’s Disease. This evidence concerns the gene HTRA1 and Alzheimer disease.