HTRA1 and early-onset autosomal dominant Alzheimer disease: Since prior studies with purified HTRA1 protein demonstrated similar effects with other aggregation-prone proteins such as FUS, TDP-4319 and fibrillar tau26,27, it would be of interest to examine whether NALL treatment exhibited protective effects in models of amyotrophic lateral sclerosis, frontotemporal dementia, and Alzheimer’s Disease.