From the study, it is evident that the absence of HSP70 exacerbates NLRP3-dependent peritonitis and enhances caspase-1 activation and IL-1β production in bone marrow-derived macrophages (BMDMs) of mice, while also increasing the number and size of ASC/NLRP3 specks (68). This evidence concerns the gene NLRP3 and peritonitis.