Tumor Inhibition: Only the harmful effects of DMH-induced colon carcinogenesis were protected against by S.mansoni antigen administration, which also resulted in a notable reduction in the average lesion size and number of neoplasias per animal.Immunological Response: a noteworthy drop in serum IL-17, a noteworthy rise in serum IL-10, and a notable proportion of intestinal FoxP3+ Treg cells and splenic CD4+T cells. Here, FOXP3 is linked to neoplasm.