Tumor Inhibition: rTcCalr binds to scavenger receptors, reducing the formation of new blood vessels in the tumor, thereby decreasing the supply of nutrients and oxygen essential for tumor growth and metastasis​​.Immunological Response: rTcCalr increases the expression of MHC I while decreasing the expression of MHC II, which helps enhance the recognition and attack of tumor cells by CD8+ T cells​​. Here, CD8A is linked to neoplasm.