TNF and neoplasm: Tumor Inhibition: Both in vivo and in vitro, osteosarcoma cells were driven to undergo apoptosis by anti-TPD52 antiserum.Immunological Response It was shown that injecting anti-TPD52 antiserum into nude mice increased their serum levels of TNF-α, IL-12, and IFN-γ using an enzyme-linked immunosorbent assay.