COMT and Parkinson disease: We comprehensively investigated whether genetic variation within COMT influences PD risk, LID, cognitive impairment, motor function, and complications, utilizing large-scale array-based genotyping and whole-genome sequencing (WGS) data from the Global Parkinson’s Genetics Program (GP2) [12] and the Accelerating Medicines Partnership - Parkinson Disease (AMP-PD) initiatives.