For example, although the association signals between LDL cholesterol and T2D at the HMGCR locus do not colocalise with each other (42), the two lead variants are in moderate LD (r2 = 0.53), which could likely bias our cis-MR estimates for T2D (Figure 2A) at this locus. This evidence concerns the gene HMGCR and type 2 diabetes mellitus.