Significant behavioral abnormalities, decreased antioxidant defense, and an increase in inflammatory markers such as GFAP, iNOS, intercellular adhesion molecule (ICAM), and tumor necrosis factor-gamma (TNF-γ) were observed in pars compacta of substantia nigra (SNpc) of the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) -induced PD mouse model. This evidence concerns the gene NOS2 and Parkinson disease.