To summarize, different MO extracts have beneficial effects in decreasing IL-1β, I-6, TNF-α, iNOS, NF-κB p65, NO, GFAP, IBA1, IL-8, TLR4, TLR2, MyD88 and increasing levels of IL-4 and IL-10 suggesting that MO exerts its neuroprotective effect via TLR4/2-MyD88/NF-κB signaling in various neurological disorders. Here, TLR4 is linked to nervous system disorder.