In the AD mouse model, APPsw/Tg2576 mouse, long-term (15 months) dietary supplementation of dates (4%) reduced several cytokines including TNF-α, IL-1β, IL-2, IL-3, IL-4, IL-5, IL-6, etc. and exotoxin activity in plasma of this transgenic AD animal model in comparison to the untreated disease model. The gene discussed is IL1B; the disease is Alzheimer disease.