As to tumour pathological features, the rate of Fn+ usually increases with the depth of tumour invasion (T), poor tumour differentiation (de Carvalho et al., 2019; Haruki et al., 2020; Joo et al., 2024; Liu et al., 2018; Mima et al., 2015; Sun et al., 2016; Wei et al., 2016), neural invasion, and with the presence of nodal (N) (Castellarin et al., 2012; Yamaoka et al., 2018; Yan et al., 2017), and distant metastasis (M) (Chen et al., 2022), although such results have not been entirely confirmed (Tahara et al., 2014; Ito et al., 2015; Chen et al., 2019, 2022; Eisele et al., 2021). This evidence concerns the gene FN1 and neoplasm.