They confirmed the significant correlation between Fn and BRAF p.V600E somatic mutation and CIMP-high CRC (Table 2), yet the Fn enrichment in hereditary cancers also indicates the importance of the MMR-deficient tumour microenvironment for the colonization, irrespectively of the origin of the defect (Joo et al., 2024). This evidence concerns the gene FN1 and colorectal carcinoma.