FN1 and colorectal carcinoma: Zhang et al. found that, mechanistically, Fn activated the TGF-β1/SMAD signalling pathway to promote EMT via the miR-122-5p/FUT8 axis, stimulating CRC cells to excrete exosome-wrapped miR-122-5p, and activating the FUT8/TGF-b1/Smads axis to promote metastasis (Zhang et al., 2023).