Most recently, in vitro experiments by Kong et al. demonstrated that Fn-induced NETs indirectly accelerated malignant tumour growth through angiopoiesis and facilitate tumour metastasis via EMT-related cell migration, matrix metalloproteinase (MMP)-mediated degradation of basement membrane proteins, and the subsequent trapping and dissemination of CRC cells (Kong et al., 2023). Here, FN1 is linked to colorectal carcinoma.