CD163 and neoplasm: Lee et al. (2021) reported that, among MSI CRCs, the Fn-high subset was composed of larger tumours with deeper pT stage (as to the prevalence of pT3–pT4 tumours), which harboured less dense FoxP3+ TILs (at tumour centre and invasive margin) but denser CD163+ tumour associated macrophages in the tumour centre (Cavalleri et al., 2019).