While the prevalence of Fn in biofilms might be similar in different colon districts, the prevalence of invasive Fn in right-sided cancers approached 90% versus 42% of distal ones, and no relationship was found between biofilm positivity and tumour invasion by Fn. Interestingly, these authors also reported the presence of Fn in all tested metastatic lymph nodes (Yu et al., 2016). This evidence concerns the gene FN1 and neoplasm.