The most promising therapeutic agents for the treatmentof CF turned out to be a group of modulators, which aresmall molecule drugs that were identified as a result ofhigh-throughput screening to correct impaired CFTR proteintransport to the plasma membrane or to increase the conductanceof the chloride channel (Dechecchi et al., 2018; Sui etal., 2022; Krasnova et al., 2023). The gene discussed is CFTR; the disease is cystic fibrosis.