MTOR and Sepsis: In a sepsis model, H2 regulates macrophage polarization (inhibiting the M1 phenotype/promoting the M2 phenotype) and inhibits mammalian target of rapamycin (mTOR) phosphorylation, reducing the release of inflammatory mediators such as IL‐6, TNF‐α, and HMGB1, while increasing the levels of anti‐inflammatory factors IL‐10 and Transforming Growth Factor‐beta (TGF‐β) [47].