[44] demonstrated that inhalation of 4% H2 in an NAFLD rat model significantly lowered plasma LPS levels, inhibited the LPS/TLR4/NF‐κB signaling pathway to reduce liver inflammation, and enhanced intestinal barrier function by upregulating Zo‐1 and occludin expression. Here, NFKB1 is linked to metabolic dysfunction-associated steatotic liver disease.