TET2 and posterior cortical atrophy: Kaplan-Meier analysis delineated three significant predictors of inferior OS in TZ PCa: advanced pathological T stage (T2-4 vs T1c, p<0.001), elevated Gleason score (≥4 + 3 vs ≤3 + 3, p=0.005), and TET2-mutant status (mutant vs non mutant, p<0.001) (Figures 4B-D).