Multivariate logistic regression analysis revealed that gender (OR: 2.612, 95% CI 1.132 to 6.123, p = 0.021), SOFA score (OR: 1.133, 95% CI 1.051 to 1.179, p = 0.033), shock index (SI) (OR: 1.122, 95% CI 1.097 to 1.370, p = 0.031), blood urea nitrogen (BUN) (OR: 1.015, 95% CI 1.010 to 1.0203, p = 0.048), albumin level (OR: 0.444, 95% CI 0.222 to 0.887, p = 0.022), and diabetes (OR: 1.388, 95% CI 1.134 to 1.189, p = 0.01) were independent risk factors for GIB in patients with TBI. This evidence concerns the gene ALB and diabetes mellitus.