Physiologically, the progression of kidney disease leads to the accumulation of uremic toxins and increased inflammatory cytokines, such as interleukin-6 (IL-6), which negatively affect brain function and mood regulation, thereby linking kidney disease to depressive symptoms (Jayakumar et al., 2023; Yuan et al., 2021; Bugnicourt et al., 2013; Liu et al., 2024a). This evidence concerns the gene IL6 and kidney disorder.