Subsequently, we found the most significant (Benjamini–Hochberg, FDR q < 0.001) annotations related to thyroid cancer to be apoptotic (GO:0097190), sphingolipid (KEGG:04071), neurotrophin (KEGG:04722), FoxO (KEGG:04068), p53 (KEGG:04115), ErbB (KEGG:04012), MAPK (KEGG:04010), PI3K-AKT-mTOR (WP:WP3844), and TNF-α (WP:WP231) signaling pathways. The gene discussed is TP53; the disease is thyroid gland carcinoma.