Moreover, the expression of Sirt1 was downregulated in the hearts of PF mice as revealed by both immunohistochemistry and immunoblots compared to control group, whereas wogonin treatment significantly increased the levels of Sirt1 (Figures 6C, D), highlighting the importance of Sirt1 in wogonin’s cardioprotective effects. Here, SIRT1 is linked to pemphigus foliaceus.