The selective LH/follicle-stimulating hormone (FSH) suppression (>10:1 ratio) of these antagonists (13, 14) preserves follicular synchronization and supports GnRH agonist triggering, reducing moderate-to-severe OHSS incidence by 62% [odds ratio (OR) = 0.38] (15). This evidence concerns the gene PLOD1 and ovarian hyperstimulation syndrome.