Zhang et al. studied CAFs and COL6A1 in OS and found that, in addition to the above EMT and metastasis mechanisms, COL6A1 overexpressing CAFs increased the proportion of CD133+ (a stem cell biomarker) cells in OS by secreting TGF-β, suggesting that they promoted the stemness of OS tumor [28]. The gene discussed is TGFB1; the disease is neoplasm.