CGAS and neoplasm: For the detection of cGAS-STING signal activation in vivo, the shDaxx combined with the OXA group shows elevated expressions of p-TBK1, IFN-β, IFN-γ, and GZMB compared with the single OXA group, suggesting that Daxx knock-down triggered STING-mediated interferon signals and immune responses to inhibit tumor growth (Fig. 7C–F).