PTPN11 and neoplasm: Furthermore, the dephosphorylation of poly (ADP-ribose) polymerase 1 (PARP1) by SH2 domain-containing protein-tyrosine phosphatase-2 (SHP2) inhibits DNA repair and promotes STING-mediated antitumor immunity response, suggesting that tumor intrinsic STING activation is also important for chemotherapy [27–29].