Aside from SS18-SSX, high levels of the transcriptional corepressor named Transducin-like Enhancer of Split 1 (TLE1) is specifically found in most, if not all, of synovial sarcoma tumors and is thereby used as an additional way to indicate the presence of synovial sarcoma in the clinic [5]. The gene discussed is SS18; the disease is synovial sarcoma.