CircR-ASCC3 sponges miR-432-5p to promote Complement component 5a (C5a) expression, high C5a expression promotes EMT transformation and M2 type macrophage (M2-type) tumor-associated macrophages expression through depletion of CD8+ T cells, and ultimately enhances NSCLC progression and immune escape [121]. This evidence concerns the gene CD8A and non-small cell lung carcinoma.