Coactivator-associated arginine methyltransferase 1 (CARM1), as a negative regulator of anti-tumor immunity, was found to down-regulate the expression of CD8+ T cells, dendritic cells (DCs) and natural killer cells (NK cells) and inhibit γ-interferon (IFN-γ) signaling, leading to tumor immune escape and immune drug resistance [123]. The gene discussed is CD8A; the disease is neoplasm.