LncR-LOC85009 competitively binds to ubiquitin-specific peptidase 5 (USP5) in order to destabilize the upstream transcription factor 1 (USF1) protein, which inactivates ATG5 transcription, inhibits autophagy and reverses DTX resistance in NSCLC cells [206]. The gene discussed is USP5; the disease is non-small cell lung carcinoma.