NcRNAs regulate the expression of genes with specific functions (for example: DNA damage repair, cancer cell stemness, apoptosis, autophagy, EMT), and cancer development-associated Mitogen-activated protein kinase/Snail family transcriptional repressor 2 (MAPK/Slug), PI3K/AKT, and Wnt/β-catenin signaling pathways to alter the therapeutic effect of DDP. The gene discussed is AKT1; the disease is cancer.