PTEN is a target of miR-142-5p, circR-0000190 improves PTEN expression and inhibits the PI3K/AKT signaling pathway through down-regulation of miR-142-5p, which ultimately enhances the immune escape and immune resistance of PD-L1-mediated NSCLC cells [125,126]. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.