Moreover, the expression of circR-CELF1/EGFR is negatively correlated with CD8+ T cells in NSCLC, and the up-regulation of circR-CELF1 facilitates the tumor immune escape and resistance to anti-PD-1 inhibitor through reducing the number of CD8+ T cells [120]. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.