TRIM21 and non-small cell lung carcinoma: LncR-02418 acts as a negative regulator of PD-L1 expression and promotes Tripartite motif-containing protein 21 (TRIM-21)-mediated ubiquitination of PD-L1, which results in up-regulation of CD8+ T cells expression and increased sensitivity of NSCLC cells against PD-L1 inhibitors [103].