Long non-coding RNA X-inactive specific transcript (LncRNA-XIST) down-regulates the target miR-34a-5p to increase the expression of PD-L1 and inhibit the immune function of CD8+ T cells, which promotes the growth, migration and invasion of lung cancer, possibly mediating the resistance to anti-PD-L1 inhibitors [138]. This evidence concerns the gene CD8A and lung cancer.