Using LASSO regression analysis (Fig. 1C), we examined five signature genes, whose risk scores are capable to predicting the prognosis of GC accurately: Risk Score = 0.3392 × CPZ + 0.0894 × CTHRC1 + 0.0468 × DKK1 + 0.2534 × EGF + 0.0687 × GPC3 (Fig. 1D). The gene discussed is EGF; the disease is gastric cancer.