For instance, POU5F1 promotes gastric cancer (GC) cell proliferation and migration by inhibiting TRAF6 ubiquitination and degradation, thereby activating the NF-κB pathway [29], and KDM48 stimulates TRAF6-mediated AKT activation and facilitates the progression of rectal cancer [30]. The gene discussed is POU5F1; the disease is rectal cancer.