Mitogen activated protein kinase (MAPK) and phosphatidylinositol-4,5-bisphosphate 3-kinase (PI3K)/protein kinase B (AKT) signaling pathways (negative regulators of autophagy) are key factors that mediate autophagy and apoptosis interactions in tumor cells [24,25]. The gene discussed is WNK2; the disease is neoplasm.