In conclusion, this study employed bioinformatics techniques, including WGCNA, to identify five characteristic genes associated with cSCC: ADH1B, CCL27, ID4, LRP4 and S100A9. Additionally, we demonstrated that CCL27, ID4, LRP4 and S100A9 are correlated with the infiltration of various immune cell types in cSCC. The gene discussed is CCL27; the disease is skin squamous cell carcinoma.