Previous studies have found that knocking down Piezo2 in rat DRG neurons significantly alleviates visceral hypersensitivity caused by acetic acid enema.10 Comparable observations were made in the 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced post-inflammatory (PI)-IBS mouse model.21 However, our study distinguished itself by employing an IBS model induced by FMT, which provides a unique perspective compared to chemical-induced (acetic acid/TNBS) IBS model. The gene discussed is PIEZO2; the disease is irritable bowel syndrome.