Men have higher rates of obesity than women.Women with bilateral primary aldosteronism seem to have a higher cardiometabolic burden (obesity, diabetes, dyslipidaemia) than those with unilateral primary aldosteronism.Among patients with bilateral primary aldosteronism, women may be more likely than men to have deterioration of renal function after starting mineralocorticoid receptor antagonists. The gene discussed is NR3C2; the disease is primary aldosteronism.