Women < 50 years are more likely to have unilateral primary aldosteronism than older women.Somatic KCNJ5 and CTNNB1 mutations are more common in women (female-to-male ratio 1.6-4.4:1 and 2:1, respectively).Somatic ATP1A1 and CACNA1D mutations are more common in men (female-to-male ratio ∼0.2:1 and ∼0.3:1, respectively).Somatic SLC30A1 mutations have been reported exclusively in men. The gene discussed is CTNNB1; the disease is primary aldosteronism.