Increased methylation of CpG residues is also seen upstream of the expanded repeats in DM1 (OMIM #160900), an autosomal dominant disorder characterized by a CTG repeat expansion in the 3’ UTR of the Dystrophy Myotonic Protein Kinase (DMPK) gene [24, 25]. The gene discussed is DMPK; the disease is myotonic dystrophy type 1.