The following variables had significant associations with the occurrence of early cardiac inflammatory adverse events in univariate analysis: anti-PD-L1 agent at index, combination ICI therapy at index, prior history of CHF, history of PVD, history of CEVD, history of HTN, history of aspirin, history of anti-coagulant, and history of atypical antipsychotic (Supplemental Table 4). This evidence concerns the gene CD274 and hypertensive disorder.