For example, circMYBL2 enhances the efficiency of FLT3 kinase translation by facilitating polypyrimidine tract-binding protein 1 (PTBP1) binding to FLT3 mRNA, thereby promoting proliferation and inhibiting differentiation in FLT3-ITD-positive AML cells [46]. This evidence concerns the gene FLT3 and acute myeloid leukemia.