Collectively, the available evidence suggests that circRNAs may be degraded by GW182 (a crucial component of the P-body and RNAi machine) [34], RNase L in cells upon poly(I:C) treatment or viral infection [35], or by interacting with miRNAs in an Argonaute 2 (Ago2)-dependent manner [36]. This evidence concerns the gene AGO2 and viral infectious disease.