Notably, this set included P4HB, a member of the PDI family, two known ALS-causing proteins (TUBA4A and VCP) [30], along with proteins implicated in the KEGG ALS interactome [31] (ATP5A1, HSPA5, TUBA1A, TUBA4A, and VCP). This evidence concerns the gene HSPA5 and amyotrophic lateral sclerosis.