The 26 shared ALS interactome proteins also included multiple members of several protein families and complexes: two ATP synthase subunits (ATP5A1 and ATP6V1A), six chaperonins containing T-complex components (CCT2, CCT3, CCT4, CCT5, CCT7, and CCT8), three thioredoxin domain proteins (P4HB, PRDX1, and PRDX2), and four members of the 14-3-3 family (YWHAB, YWHAE, YWHAH, and YWHAQ) (Fig. 2A). Here, P4HB is linked to amyotrophic lateral sclerosis.