The studies presented here demonstrate the presence, by energy-dependent DRAC and photocrosslinking, of a multi-protein complex in PBMCs that is related to that observed previously by the same methods in Tg ALS SOD G93A model MoBr and ALS patient-derived fibroblasts (PDFs) that display both TDP-43 mislocalization and stress-induced TDP-43 agregation [14]. Here, TARDBP is linked to amyotrophic lateral sclerosis.