GPR151 and obesity due to melanocortin 4 receptor deficiency: Ina diet-induced obesity model, GPR151 mRNA was upregulated in the hindbrainand pituitary gland but downregulated in the liver and subcutaneouswhite adipose tissue. An injection ofinsulin led to a significant downregulation of GPR151 mRNA in whiteadipose tissue, while an injection of glucagon led to an upregulationof transcript in the liver. Based onthese observations, researchers hypothesized that GPR151 plays a rolein adipocyte differentiation and hepaticgluconeogenesis, both of which are antiobesitytherapeutic targets.,,