Significantly elevated concentrations of all IFNλ subtypes (IFNλ1, IFNλ2, and IFNλ3) were induced in response to BA.2 infection across all 4 donors (p < 0.01) and 2/4 donors in response to BA.1 infection (p < 0.05), which was not observed in response to infection with the other VOCs (Fig. 2C). Here, IFNL3 is linked to infection.