In IPSC-LOs, compared to D614G, there were significantly higher levels of IL-2 (Alpha, Gamma, Delta, BA.1, p < 0.001) and IL-8 (all VOCs, with the highest levels observed in response to BA.1 infection, p < 0.0001), TNFα (Delta and BA.1 viruses, p = 0.0371 and p = 0.0015, respectively), MCP-1 (Delta, BA.1, and BA.2 viruses, p = 0.0144, 0.0015, and 0.0117), IL-6 (Delta, BA.1, and BA.2 viruses, p = 0.0483, 0.0003, <0.0001), and IL-12p70 (BA.1 virus, p = 0.0353) observed. This evidence concerns the gene CCL2 and infection.