To further support the significance of the cGAS-STING pathway in anti-tumor immune responses in cHL, inhibition of STING activity using the selective inhibitor C-176 resulted in a dramatic decrease of CXCL10 gene expression, which was associated with altered cytokine and chemokine profile (Supplementary Fig. 7). The gene discussed is STING1; the disease is classic Hodgkin lymphoma.