In this study, our objective was to explore the spectrum of somatic mutations in adolescent and young adult patients with CML in chronic phase (CML-CP) treated with adult protocol and to compare them with pediatric and adult CML patients, as well as with patients diagnosed with BCR::ABL1-positive acute lymphoblastic leukemia (Ph+ ALL). Here, BCR is linked to chronic myelogenous leukemia, BCR-ABL1 positive.