CCL2 and COVID-19: Of note, both KYA1797K and E7449 both reduced expression of the proinflammatory cytokines CCL2 and CXCL-10 in mouse lungs, but only E7449 significantly reduced expression of IL-6, which together with CCL2 and CXCL-10, is a biomarker for severe disease in COVID-19 patients (reviewed in ref. 52).