Of note, both KYA1797K and E7449 both reduced expression of the proinflammatory cytokines CCL2 and CXCL-10 in mouse lungs, but only E7449 significantly reduced expression of IL-6, which together with CCL2 and CXCL-10, is a biomarker for severe disease in COVID-19 patients (reviewed in ref. 52). The gene discussed is CXCL10; the disease is COVID-19.