Several host cell receptors are known to facilitate filovirus entry, such as various C-type lectins (CLECs) that bind viral glycoprotein (GP), members of the TAM family of receptors such as Axl, Mer and Tyro3, Niemann-Pick disease, type C1 (NPC1), dendritic cell-specific ICAM-3-grabbing non-integrin (DC-SIGN) and macrophage galactose-type lectin (MGL)8,40. The gene discussed is NPC1; the disease is Pick disease.