ISG15 and infection: Starting at 1-day post-infection, EBOV induces defined shifts in the transcriptional profile of human moMΦs, including the upregulated gene expression of various Type I IFN genes, OASL, ISG15, and ISG20, IFIT1, IFIT2 and IFIT3, and chemokines like CCL5 and CXCL10, all of which were also found as significantly upregulated in our own findings for MARV.