APOE and Alzheimer disease: Given the growing relevance of APOE in biomedical research, particularly in neurodegenerative diseases like AD, a genetic analysis was performed on individuals from the AFA associations in Soria, Salamanca, León, and Ponferrada, as well as from ‘Mensajeros de la Paz’ Residences in Mansilla de las Mulas and La Bañeza (León).