tRF/miR-1280, a 17-bp fragment derived from tRNA-Leu in colorectal cancer and pre-miRNA, could directly target Notch ligand JAG2 with the functional consequence of inactivation of Notch signaling suppressed CSC phenotypes by direct transcriptional repression of the Gata1/3 and miR-200b genes constantly elevated levels of JAG2, Gata1, Gata3, Zeb1, and Suz12 [53]. This evidence concerns the gene SUZ12 and colorectal cancer.