Another study from chronic lymphocytic leukemia and lung cancer showed that ts-3676, ts-4521, ts-46, ts-47, ts-49, ts-53, and ts-101 were down-regulated and mutated, which can form complexes by interacting with Piwi-like protein 2 (PIWIL2) [57]. The gene discussed is PIWIL2; the disease is B-cell chronic lymphocytic leukemia.