Moreover, overexpression of PRPS2 was strongly associated with poorer patient prognosis across various cancer types, including lung cancer, breast cancer, pancreatic adenocarcinoma, brain lower-grade glioma cancer, mesothelioma, and esophageal carcinoma (Fig. 1h-k, Supplementary Fig. 3-5). The gene discussed is PRPS2; the disease is breast cancer.