In the MPR_Pre-NAIC_Tumor and MPR_Post-NAIC_Tumor groups, CD4+ T cells were enriched with the CXCL13 signaling pathway and T cell-induced cell death process, whereas the Tregs differentiation process was weakly enriched in the MPR_Post-NAIC_Tumor. The gene discussed is CXCL13; the disease is neoplasm.