SHANK2 and neurodevelopmental disorder: Additional genes involved in synaptic neuroplasticity include the proteins cortactin binding protein 2 (CTTNBP2), SHANK2 (also known as Cortactin Binding Protein 1), Neuroligin 1 (NLGN1), and the calcium channel subunit CACNA1C. CTTNBP2, SHANK2, and NLGN1 are cytoskeletal proteins found in the postsynaptic density, which have been previously associated with neurodevelopmental disorders and are key components of glutamatergic spine formation and synaptic neuroplasticity71.