LDHA and familial pancreatic carcinoma: As demonstrated by Liang et al., nucleolar and spindle-associated protein 1 (NUSAP1) Kla modulates the expression of LDHA in pancreatic cancer; this results in the formation of an NUSAP1 Kla-LDHA-glycolysis-lactate feed-forward loop, serving as a possible mechanism underlying the metabolic propensity of glycolysis in pancreatic cancer [100].