Moreover, a reduction in lactate is achieved through the genetic depletion of lactate dehydrogenase A (LDHA) or stiripentol, an inhibitor of lactate dehydrogenase A used in clinical settings to treat epilepsy, which inhibits NBS1 K388 lactylation, reduces the effectiveness of DNA repair, and overcomes chemotherapy resistance [82]. Here, LDHA is linked to epilepsy.