CD8A and autoimmune disease: Nevertheless, both Ikzf2−/− and Treg-specific Ikzf2−/− mice develop progressive autoimmune disease associated with activated CD4+/CD8+ T cells, increased T follicular helper (TFH) and germinal center (GC) B cell numbers, autoantibody production, and increased proinflammatory cytokine production [26, 27, 35].