Collectively, these germline LOF IKZF2 variants were predominantly heterozygous (10/13) and were mostly associated with evidence of immune dysregulation (10/13) (Table S4), including systemic lupus erythematosus (SLE), hemophagocytic lymphohistiocytosis (HLH), idiopathic thrombocytopenic purpura (ITP), and Evan’s syndrome. The gene discussed is IKZF2; the disease is autoimmune thrombocytopenic purpura.