Notably, loss-of-function (LOF) variants in IKZF2 (HELIOS) were recently associated with combined immunodeficiency (CID) and/or immune dysregulation, including immune thrombocytopenia (ITP), Evan’s syndrome, and systemic lupus erythematosus [9–11]. This evidence concerns the gene IKZF2 and systemic lupus erythematosus.