With respect to PXR activation and its critical role in triazole-induced steatosis (Knebel et al. 2018), it is plausible to assume that DIF and MDP act via dissimilar MoAs, consistent with CAG grouping as MDP is not included in the hepatocellular fatty changes CAG (Nielsen et al. 2012). This evidence concerns the gene NR1I2 and steatosis.